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Preoperative and postoperative cytokines in patients with cancer
Author(s) -
Nakazaki Haruhiro
Publication year - 1992
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19920801)70:3<709::aid-cncr2820700328>3.0.co;2-o
Subject(s) - medicine , hepatocellular carcinoma , carcinoma , cytokine , tumor necrosis factor alpha , gastroenterology , cancer , interleukin 6 , interleukin
Background. Changes in tumor necrosis factor‐alpha (TNF‐α), interleukin‐1 alpha (IL‐1α), interleukin‐1 beta (IL‐1β), interleukin‐6 (IL‐6), and granulocyte macrophage‐colony‐stimulating factor (GM‐CSF) were investigated before and after operation in patients with hepatocellular carcinoma (HCC), metastatic liver carcinoma, and gastrointestinal carcinoma. Results. Serum levels of TNF‐α, IL‐1α, and IL‐1β were high in patients with liver carcinoma (HCC and metastatic liver carcinoma) before operation in comparison with those of normal controls (P < 0.01). In patients with gastrointestinal carcinoma, serum levels of cytokines, except those of TNF‐a, were the same as in patients with liver carcinoma. The level of TNF‐α in patients with gastrointestinal carcinoma was low compared with that in patients with liver carcinoma. Within 1 day after operation, the peak level of TNF‐a was observed at 15 hours, IL‐1α at 18 hours, IL‐1β at 21 hours, and IL‐6 at 24 hours after operation. Subsequently, these cytokine levels peaked again: TNF‐α at 48 hours, IL‐1α at 72 hours, IL‐1β at 120 hours, and IL‐6 at 168 hours after operation. GM‐CSF levels increased gradually after operation. Moreover, in HCC, serum levels of TNF‐α were high in patients with recurrence compared with those without recurrence (P < 0.01). The difference in IL‐1α and IL‐1β levels between patients with recurrence and those without recurrence can be regarded as significant (P < 0.01). Conclusion. These results suggest that TNF‐α, IL‐1, IL‐6, and GM‐CSF may play an important role in the pathogenesis of cancers; TNF‐α may be especially important as a tumor marker in HCC and metastatic liver carcinoma. Cancer 1992; 70:709–713.