Premium
Precursor langerhans cell histiocytosis
Author(s) -
Segal Glenn H.,
Mesa M. Vincent,
Fishleder Andrew J.,
Stoler Mark H.,
Weick James K.,
Lichtin Alan E.,
Tubbs Raymond R.
Publication year - 1992
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19920715)70:2<547::aid-cncr2820700227>3.0.co;2-z
Subject(s) - birbeck granules , langerhans cell histiocytosis , histiocyte , precursor cell , medicine , pathology , langerhans cell , lymphoma , histiocytosis , leukemia , malignant histiocytosis , haematopoiesis , cancer research , cell , immunology , biology , stem cell , antigen , microbiology and biotechnology , genetics , disease
Background . Langerhans cell precursors are considered to be identical to their mature counterparts except for the lack of Birbeck granules. Proliferations composed of such histiocytes appear to be uncommon. Methods . Standard immunophenotypic, molecular genetic, and DNA content studies were used to characterize various hematopoietic disorders, including a proliferation of precursor Langerhans cells, which arose sequentially in a patient. Results . The patient studied initially had a low‐grade, B‐cell, non‐Hodgkin lymphoma and subsequently had an unusual histiocytic proliferation (precursor Langerhans cell histiocytosis) in cutaneous and lymph node sites. The patient eventually died of acute myelogenous leukemia (FAB, M5). Conclusions . A larger series is required to determine the significance of the precursor Langerhans cell phenotype, particularly with respect to the development of acute myelogenous leukemia. Cancer 1992; 70: 547‐553.