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Regressing atypical histiocytosis, a regressing cutaneous phase of ki‐i‐positive anaplastic large cell lymphoma. Immunocytochemical, nucleic acid, and cytogenetic studies of a new case in view of current opinion
Author(s) -
Motley R. J.,
Jasani B.,
Ford A. M.,
Poynton C. H.,
CalonjeDaly J. E.,
Holt P. J. A.
Publication year - 1992
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19920715)70:2<476::aid-cncr2820700216>3.0.co;2-5
Subject(s) - medicine , pathology , lymphoma , cancer research
Background . Regressing atypical histiocytosis is a rare multifocal cutaneous tumor characterized by large, spontaneously regressing, ulcerating skin nodules. Although initially self‐remitting, the condition may progress to systemic lymphoma. Methods . Using material from one patient, an attempt was made to clarify the nature of this condition with immunophenotyping, genotyping, and chromosome studies. Results . Immunophenotyping studies indicated the condition was of T‐cell lineage, although T‐cell receptor gene studies showed polyclonal rearrangement. This case progressed to systemic lymphoma. Conclusions . The authors believe regressing atypical histiocytosis is a regressing phase of Ki‐1‐positive anaplastic large cell lymphoma of the skin. Cancer 1992; 70:476–483.