Premium
Clonal evolution in primary 5q‐ syndrome
Author(s) -
Wong K. F.,
Chan J. K. C.,
Chu Y. C.,
Kwong Y. L.
Publication year - 1992
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19920701)70:1<100::aid-cncr2820700116>3.0.co;2-f
Subject(s) - thrombocytosis , somatic evolution in cancer , medicine , primary (astronomy) , malignant transformation , karyotype , pathology , immunology , genetics , cancer , biology , gene , platelet , chromosome , physics , astronomy
Primary 5q‐ syndrome is a type of myelodysplastic syndrome characterized by refractory anemia, thrombocytosis, and hypolobulated megakaryocytes. The risk of leukemic transformation is low. A case of 5q‐ syndrome that occurred in a 42‐year‐old woman and was complicated by leukemic transformation 7 years after the initial diagnosis is reported. An additional clonal karyotypic anomaly, del(7q), was seen in the leukemic cells. The literature on leukemic and karyotypic evolution of primary 5q‐syndrome is reviewed and the implication of karyotypic evolution is discussed.