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Expression of transforming growth factor‐alpha in gastric carcinoma and normal gastric mucosa cells
Author(s) -
Muller W.,
Borchard F.
Publication year - 1992
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19920615)69:12<2871::aid-cncr2820691202>3.0.co;2-7
Subject(s) - malignancy , immunohistochemistry , medicine , pathology , transforming growth factor , gastric mucosa , alpha (finance) , stage (stratigraphy) , tgf alpha , stomach , carcinoma , cancer , gastric carcinoma , biology , paleontology , construct validity , nursing , epidermal growth factor receptor , patient satisfaction
The presence of transforming growth factor‐α (TGF‐α) was studied in a total of 120 consecutive patients with gastric carcinomas. This immunohistochemical study found TGF‐α expression in 60% (n = 72) of carcinomas. It also was detected in normal gastric epithelial mucosa in 36% (n = 43) of specimens. There was no significant statistical correlation between TGF‐α expression and clinical features (e.g., patient age and sex) or pathologic features (e.g., tumor stage, grade, and localization or growth pattern according to an earlier histologic classification). Expression of TGF‐α by these tumor cells had no influence on prognosis. It was neither a histopathologic marker of high malignancy nor a useful prognostic tool. It had no influence on the invasive growth pattern of gastric carcinoma.