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Castleman's disease in poems syndrome with elevated interleukin‐6
Author(s) -
Mandler Raúl N.,
Kerrigan Daniel P.,
Smart Joanne,
Kuis Wietse,
Villiger Peter,
Lotz Martin
Publication year - 1992
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19920601)69:11<2697::aid-cncr2820691112>3.0.co;2-3
Subject(s) - poems syndrome , medicine , organomegaly , plasma cell dyscrasia , dyscrasia , polyneuropathy , pathology , disease , hyperplasia , pathogenesis , plasma cell , immunology , antibody , bone marrow , immunoglobulin light chain
POEMS syndrome is a rare multisystem affliction known for its signs, from which it also takes its acronym name “peripheral neuropathy, organomegaly, endocrinopathy, monoclonal (M) protein, and skin lesions.” Our study chronicles the course of this syndrome in a young woman with Castleman's disease (angiofollicular lymph node hyperplasia). Cerebrospinal fluid (CSF) and serum interleukin‐6 (IL‐6) levels were abnormally elevated at various times during a %month period. The authors conclude that the plasma cell dyscrasia associated with the POEMS syndrome of this patient was Castleman's disease. Elevation of serum IL‐6 levels might contribute to the pathogenesis of the POEMS syndrome. Cancer 1992; 69:2697‐2703.