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Successful treatment of angioimmunoblastic lymphadenopathy with dysproteinemia with cyclosporin A
Author(s) -
Murayarna Tohru,
Lmoto Shion,
Takahashi Tetsuya,
Ito Mitsuhiro,
Matozaki Sachiko,
Nakagawa Toshitaro
Publication year - 1992
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19920515)69:10<2567::aid-cncr2820691029>3.0.co;2-m
Subject(s) - medicine , chemotherapy , refractory (planetary science) , cervical lymphadenopathy , lymphoma , disease , dermatology , surgery , pathology , physics , astrobiology
Angioimmunoblastic lymphadenopathy with dysproteinemia (AILD) is a lymphoma‐like disease. Although the histologic appearance of this disease is benign, it is clinically malignant, with chemotherapy being ineffective and the prognosis being poor. In this article, the authors report the results of treating two patients with AILD with cyclosporin A. One patient had cervical lymphadenopathy and fever, and AILD was refractory to both chemotherapy and a‐interferon. However, treatment with cyclosporin A achieved complete remission. The other patient had generalized lymphadenopathy, and cyclosporin A was used as the treatment of first choice. Complete remission also was achieved in this patient, who still is in remission. These two cases demonstrate that cyclosporin A can be effective for treating AILD.