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Absence of correlation between nuclear morphometry and survival in stage I non‐small cell lung carcinoma
Author(s) -
Cagle Philip T.,
Langston Claire,
Fraire Armatzdo E.,
Roggli Victor L.,
Greenberg S. Donald
Publication year - 1992
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19920515)69:10<2454::aid-cncr2820691012>3.0.co;2-k
Subject(s) - medicine , stage (stratigraphy) , lung , carcinoma , correlation , pathology , oncology , biology , paleontology , geometry , mathematics
To evaluate the utility of nuclear morphometry as a prognostic indicator in lung cancer, 5‐year follow‐up information was obtained in 46 cases of surgically resected Stage I non‐small cell lung cancer (NSCLC). Nuclear area, perimeter, major diameter, minor diameter, and nuclear shape factor were determined from representative histologic sections of the tumors with a computer‐assisted digitizing system. The morphometric parameters were compared between patients with favorable outcome (Group I: alive with no evidence of disease, n = 17) and those with poor outcome (Group 11: dead of disease or with recurrence of disease, n = 29). No significant differences in any of the morphometric parameters were found between tumors in Groups I and II for individual tumor cell types or the combined cases. Failure to demonstrate a correlation between morphometric parameters and prognosis in Stage I NSCLC indicates that future efforts to determine objective prognostic factors should concentrate on other variables, such as specific genetic abnormalities. Cancer 1992: 69:2454‐2457.