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Carcinoembryonic antigen levels of peripheral and draining venous blood in patients with colorectal cancer. Correlation with survival
Author(s) -
Tabuchi Yoshiki,
Deguchi Hiroyuki,
Imanishi Kizuku,
Saitoh Yoichi
Publication year - 1992
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19920515)69:10<2411::aid-cncr2820691005>3.0.co;2-p
Subject(s) - medicine , carcinoembryonic antigen , colorectal cancer , peripheral blood , venous blood , peripheral , cancer , oncology , gastroenterology
Correlations between preoperative carcinoembryonic antigen (CEA) levels of peripheral (p‐CEA) and draining blood (d‐CEA), the CEA gradient between d‐CEA and p‐CEA (d‐p CEA gradient) levels, and survival after resection of cancer lesions were examined in 94 patients with colorectal cancer. Survival rates of patients with normal p‐CEA and d‐CEA levels and d‐p CEA gradient levels (<5 ng/ml) were significantly better than those of patients with abnormal levels (≥5 ng/ml), and the 5‐year survival rates were, respectively, 62%, 69%, and 72% in the former and 42%, 41%, and 35% in the latter. The differences in the 5‐year survival rates between patients with normal and abnormal d‐p CEA gradient, d‐CEA, and p‐CEA levels were 37%, Z8%, and 20%, respectively. Furthermore, the positive rates of d‐CEA levels (64%) and d‐p CEA gradient levels (48%) were higher than that of p‐CEA levels (36%). However, some significant differences in background variables also were found between the respective groups of patients with normal and abnormal p‐CEA and d‐CEA levels and d‐p CEA gradient levels. These results suggest that patients with poor prognoses are examined more effectively by determining their d‐p CEA gradient and d‐CEA levels than their p‐CEA levels, and that CEA may be expressed as a quantitative sum total of various pathophysiologic variables of patients with colorectal cancer but not as an independent prognostic variable. Cancer 1992; 69:2411‐2417.