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Epithelioid sarcoma. Flow cytometric study of dna content and regional dna heterogeneity
Author(s) -
ElNaggar Adel K.,
Garcia Glenn M.
Publication year - 1992
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19920401)69:7<1721::aid-cncr2820690713>3.0.co;2-3
Subject(s) - dna , ploidy , sarcoma , pathology , medicine , flow cytometry , oncology , biology , immunology , genetics , gene
The DNA content and regional DNA heterogeneity in correlation with clinicopathologic parameters and patient survival were investigated in epithelioid sarcoma. Such neoplasms preponderantly manifest diploid DNA content and a remarkably stable intratumoral and inter‐tumoral DNA content. Small tumor size (< 5.0 cm) and low S‐phase fraction (< 5%) were significant prognostic factors in this study. Ploidy status, mitotic rate, age, and postsurgical treatment were not significantly correlated with survival.