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Age as a predictor of an aggressive clinical course for superficial bladder cancer in men
Author(s) -
Briggs Nathaniel C.,
Young Theresa B.,
Gilchrist Kennedy W.,
Vaillancourt Allison M.,
Messing Edward M.
Publication year - 1992
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19920315)69:6<1445::aid-cncr2820690623>3.0.co;2-s
Subject(s) - medicine , stage (stratigraphy) , bladder cancer , cancer registry , cancer , odds ratio , transitional cell carcinoma , paleontology , biology
Tumor grade and stage are two of the strongest predictors for indolent versus aggressive clinical course in bladder cancer. To identify age‐related trends in tumor aggressiveness the authors investigated the relationships of age with grade and stage. Pathologic specimens were obtained for 89% (527 of 590) of new bladder cancer cases among men older than 50 years of age reported to the state tumor registry in Wisconsin for 1988. Tumors were grouped as low grade (G1, G2) or high grade (G3), and as superficial (Ta) or invasive (≥ T1), according to the TNM system. This analysis included 485 transitional cell carcinomas (TCC) for which the authors determined stage‐stratified and grade‐stratified odds ratios for men 50 through 64 years of age and older than 65 years of age. Men older than 65 years of age with superficial TCC were more than three times as likely to have a high‐grade malignancy than men 50 through 64 years of age (P = 0.01); the odds ratio was 3.44 (95% CI = 1.28, 9.26). A relationship was not apparent for invasive TCC. Age and stage were weakly associated for low‐grade and high‐grade TCC that may be due, in part, to the strong correlation of stage with grade as a prognostic indicator. These data suggest that men in older age groups are at increased risk for superficial bladder cancer of high grade, which portends an aggressive clinical course. Cancer 1992; 69:1445‐1451.