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Acute lysis pneumopathy after chemotherapy for acute myelomonocytic leukemia with abnormal marrow eosinophils
Author(s) -
Dombret Hervé,
Hunault Mathilde,
Faucher Catherine,
Dombret MarieChristine,
Degos Laurent
Publication year - 1992
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19920315)69:6<1356::aid-cncr2820690609>3.0.co;2-b
Subject(s) - medicine , leukostasis , chemotherapy , acute leukemia , diffuse alveolar damage , acute myelomonocytic leukemia , tumor lysis syndrome , lung cancer , induction chemotherapy , respiratory disease , leukemia , acute respiratory distress , pathology , immunology , lung
Acute respiratory failure developed in two patients with hyperleukocytic acute myelomonocytic leukemia with abnormal marrow eosinophils within 1 to 3 days after the beginning of high‐dose induction chemotherapy. The presence of moderate pulmonary leukostasis before chemotherapy initiation, the simultaneous occurrence of an acute tumor lysis syndrome, the lack of evidence of any other cause of respiratory distress, and the clinical evolution lead the authors to attribute pulmonary injury to lysis of resident leukemic cells. The responsibility of eo‐sinophilic cellular constituents for the diffuse alveolar damage is discussed. Cancer 1992; 69:1356‐1361.