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A chronopharmacologic phase II clinical trial with 5‐fluorouracil, folinic acid, and oxaliplatin using an ambulatory multichannel programmable pump. High antitumor effectiveness against metastatic colorectal cancer
Author(s) -
Lévi Francis,
Misset JeanLouis,
Brienza Silvano,
Adam René,
Metzger Gérard,
Itzakhi Moshe,
Caussanel JeanPierre,
Kunstlinger Francis,
Lecouturier Sylvie,
DescorpsDeclère Adrien,
Jasmin Claude,
Bismuth Henri,
Reinberg Alain
Publication year - 1992
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19920215)69:4<893::aid-cncr2820690410>3.0.co;2-x
Subject(s) - medicine , oxaliplatin , folinic acid , colorectal cancer , oncology , fluorouracil , ambulatory , chemotherapy , phases of clinical research , docetaxel , clinical trial , circadian rhythm , cancer
A significant increase in the dose intensity of chemotherapy with fluoropyrimidines and platinum complexes has resulted from selective circadian timing and/or circadian modulation of the infusion rate. The relevance of such chronopharmacologic strategy for improving the outcome of metastatic colorectal cancer was evaluated in an extended Phase II clinical trial involving 93 patients. Cancer 1992; 69:893–899.