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Does malignant small round cell tumor of the thoracopulmonary region (askin tumor) constitute a clinicopathologic entity?. An analysis of 30 cases with immunohistochemical and electron‐microscopic support treated at the institute gustave roussy
Author(s) -
Contesso Genevieve,
LlombartBosch Antonio,
Terrier Philippe,
PeydroOlaya Amando,
HenryAmar Michel,
Oberlin Odile,
Habrand Jean Louis,
Dubousset Jean,
Tursz Thomas,
Spielmann Marc,
Genin Jean,
Sarrazin Daniele
Publication year - 1992
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19920215)69:4<1012::aid-cncr2820690431>3.0.co;2-v
Subject(s) - immunohistochemistry , pathology , medicine , sarcoma , stroma , negative stain , electron microscope , physics , optics
The morphology and clinical outcome of 30 patients with malignant small round cell tumors located in the thoracopulmonary region (Ask in tumor) are reported. Histologically, all tumors had similar patterns, with small round‐to‐oval cells and a lobulated stroma. Immunohistochemical analysis always resulted in positive staining for one or several neural markers. No significant differences were found compared with the immunomarkers in 26 typical Ewing's sarcomas located outside the thoracic wall. In three specimens, electron microscopy confirmed the presence of membrane‐bound neurosecretory granules. It was confirmed that there is a remarkable similarity among all malignant small round cell tumors, including Ask in tumor and Ewing's sarcoma. Overall survival was poor with a 2‐year rate of 38% and a 6‐year rate of 14%. Cancer 1992; 69:1012–1020.