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Intraductal Carcinoma of the Pancreas
Author(s) -
Milchgrub Sara,
Campuzano Manuel,
Casillas Javier,
AlboresSattvedra Jorge
Publication year - 1992
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19920201)69:3<651::aid-cncr2820690309>3.0.co;2-#
Subject(s) - medicine , pancreas , atypia , carcinoma , lymph node , pathology , lymph , metastasis , epigastric pain , general surgery , surgery , cancer , vomiting
Four multicentric intraductal papillary carcinomas arising in the main pancreatic duct are presented. Three of the neoplasms showed stromal invasion and metastasized to regional lymph nodes. Three patients had a long history of epigastric pain, confirming the progressive slow growth and less aggressive nature of this clinico‐pathologic entity. Histologically, all tumors were papillary, and three also showed a pseudocribriform pattern. Individual cells exhibited a range of atypia from mild to overt malignant change. Focal intestinal‐differentiation was recognized in two tumors. Despite the well‐differentiated appearance of these tumors, two patients died within 1 year of surgery. One patient with an entirely intraductal carcinoma is alive and well 3 years after surgical treatment. The fourth patient who had lymph node metastasis is alive 6 months after a Whipple's procedure.