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The clinical and histologic criteria that predict metastases from cystosarcoma phyllodes
Author(s) -
Hawkins Robert E.,
Schofield John B.,
Fisher Cyril,
Wiltshaw Eve,
McKinna J. Alan
Publication year - 1992
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19920101)69:1<141::aid-cncr2820690125>3.0.co;2-1
Subject(s) - medicine , pleomorphism (cytology) , metastasis , distant metastasis , phyllodes tumor , stromal cell , oncology , retrospective cohort study , radiology , pathology , cancer , immunohistochemistry
A retrospective study of 33 patients with cystosarcoma phyllodes was done. Eight of these patients had metastases, and the clinical and histologic criteria predicting the development of metastases were examined. The most reliable predictor was the presence of stromal overgrowth; this appears to be necessary for metastasis to occur. Other useful indicators of clinical behavior were the degree of mitotic activity, nuclear pleomorphism, and infiltrating margins. Based on these data and a literature review, the authors suggest close follow‐up of patients whose primary tumors contain areas of stromal overgrowth because, in all series combined, the risk of metastatic spread in such patients was 72% within 5 years. Among these high‐risk patients, local recurrence is another indication that metastasis is likely.