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DNA ploidy is associated with growth potential in gastric carcinoma
Author(s) -
Haraguchi Masaru,
Korenaga Daisuke,
Kakeji Yoshihiro,
Orita Hiroyuki,
Maehara Yoshihiko,
Sugimachi Keizo
Publication year - 1991
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19911215)68:12<2608::aid-cncr2820681215>3.0.co;2-y
Subject(s) - ploidy , gastric carcinoma , pathology , dna , nuclear dna , carcinoma , biology , medicine , cancer , genetics , gene , mitochondrial dna
To correlate growth potential with DNA ploidy 109 patients with early gastric carcinoma and 132 patients with advanced gastric carcinoma were studied. Early gastric carcinomas were classified by growth potential into the small mucosal type, the superficially spreading (super) type, or the expansively penetrating (Pen A)/ infiltratively penetrating (Pen B) types. Advanced gastric carcinomas were classified into funnel, column, or mountain types, each of which was divided further into expanding and infiltrative types. Cell nuclear DNA content was measured by microspectrophotometric study and classified as either low or high ploidy according to the degree of dispersion on the DNA histogram. Super type early and funnel type advanced carcinomas, characterized by superficially spreading growth, were more likely to have low DNA ploidy. In contrast, Pen A type early and column‐expanding type advanced carcinomas, characterized by expansively penetrating growth, were more likely to have high DNA ploidy. Cancer 68:2608–2611, 1991.