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Malignancies in children with human immunodeficiency virus type 1 infection
Author(s) -
Aricó Maurizio,
Caselli Désirée,
D'Argenio Patrizia,
Mistro Anna Rosa Del,
Demartino Maurizio,
Livadiotti Susanna,
Santoro Nicola,
Terragna Alberto
Publication year - 1991
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19911201)68:11<2473::aid-cncr2820681125>3.0.co;2-l
Subject(s) - hepatoblastoma , medicine , lymphoma , sarcoma , cancer , chemotherapy , immunodeficiency , virus , leukemia , immunology , pediatrics , pathology , immune system
Cancer has been closely associated with human immunodeficiency virus (HIV) infection but this is less frequent in children. Non‐Hodgkin's lymphomas represent the most frequently reported single tumor. The authors report seven cases of malignant tumors resulting from the analysis of all (n = 1321) children enrolled in the Italian Register for HIV Infection in Children. Tumors were distributed as follows: non‐Hodgkin's B‐cell lymphoma (four cases); and Kaposi's sarcoma, hepatoblastoma, acute B‐cell lymphoblastic leukemia (one case each). Hepatoblastoma had never been previously reported in HIV‐infected children. Also in the current series, non‐Hodgkin's B‐cell lymphoma is the most frequent single tumor. Five of the seven cancers belonged to the B‐cell line. All but one of the seven children have died. Specific chemotherapy was provided in three cases, with some clinical improvement. The treatment of malignancies in HIV‐infected children is hampered by increased risk of opportunistic infections often fatal even in children with apparent remission from the tumor. 68:2473‐2477, 1991.