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Helix pomatia agglutinin binding activity is a predictor of survival time for patients with gastric carcinoma
Author(s) -
Kakeji Yoshihiro,
Tsujitani Shunichi,
Mori Masaki,
Maehara Yoshihiko,
Sugimachi Keizo
Publication year - 1991
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19911201)68:11<2438::aid-cncr2820681119>3.0.co;2-#
Subject(s) - helix pomatia , medicine , staining , pathology , carcinoma , gastric carcinoma , metastasis , cancer , agglutinin , lectin , biology , immunology , ecology , snail
The authors used helix pomatia agglutinin (HPA) staining to examine 163 primary gastric carcinoma isolates, using the avidin‐biotin‐peroxidase complex method. The positive HPA staining rate was 59% (96/163) for the primary tumors, and the positive staining correlated well (with statistical significance) with tumor enlargement, penetration, lymphatic invasion, and metastasis ( P < 0.01), and with infiltrative spread ( P < 0.05). Patients with gastric cancer showing positive HPA staining had a lower survival rate ( P < 0.001), particularly when the cancer cells were present on the serosal surface. Careful follow‐up and intensive postoperative therapy are required for patients with an HPA‐positive advanced gastric carcinoma. 68:2438‐2442, 1991.