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Anaplastic large cell Ki‐1 lymphoma of bone
Author(s) -
Chan John K. C.,
Ng ChiSing,
Hui PakKwan,
Leung WaiTong,
Sin VaiChong,
Lam TaiKwan,
Chick KingWah,
Lam WingYin
Publication year - 1991
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19911115)68:10<2186::aid-cncr2820681017>3.0.co;2-d
Subject(s) - medicine , lymphoma , pathology , chemotherapy , radiation therapy , large cell , anaplastic large cell lymphoma , lytic cycle , radiology , cancer , adenocarcinoma , immunology , virus
Abstract Anaplastic large cell Ki‐1 lymphoma is an uncommon type of non‐Hodgkin's lymphoma that rarely presents primarily in the bone. Three such cases are reported. All patients were young and had bone pain; one had paraparesis as a complication of collapse of the thoracic vertebral body. The involvement was either monostotic or polyostotic. Radiologically, the lesions were lytic and had ill‐defined borders. Histologically, the large neoplastic cells had pleomorphic bizarre nuclei, prominent nucleoli, abundant deeply amphophilic cytoplasm, and paranuclear pale hof. They were admixed with variable numbers of inflammatory cells. One case each was of T‐cell, B‐cell, and non‐T non‐B lineage. All three cases showed excellent responses to chemotherapy with or without radiation therapy. Recognizing the lymphomatous nature of this highly pleomorphic tumor is important because of its potential curability with appropriate chemotherapy. Cancer 68:2186–2191, 1991.