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Nephrogenic diabetes insipidus. An unusual presentation of recurrent rectal cancer
Author(s) -
Nobels Frank,
Colemont Luc,
Goethals Marnix,
Abs Roger
Publication year - 1991
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19911101)68:9<2056::aid-cncr2820680935>3.0.co;2-4
Subject(s) - medicine , diabetes insipidus , nephrogenic diabetes insipidus , rectum , cancer , metastasis , desmopressin , surgery , urology
The occurrence of diabetes insipidus (DI) in patients with systemic cancer is caused usually by tumor metastasis to the hypothalamus or posterior pituitary. A 43‐year‐old man with DI 8 months after radical surgery for a poorly differentiated adenocarcinoma of the distal rectum is reported. A therapeutic trial of intranasal desmopressin acetate did not correct the hyposthenuria, thus localizing the defect to the kidneys. A large tumor recurrence in the pelvis caused bilateral hydroureteronephrosis, resulting in nephrogenic DI. This report shows that not all cases of DI in cancer patients are of central origin.