Premium
Prognostic factors in cystosarcoma phyllodes. A clinicopathologic study of 77 patients
Author(s) -
CohnCedermark Gabriella,
Rutqvist Lars E.,
Rosendahl Ingvar,
Silfverswärd Claes
Publication year - 1991
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19911101)68:9<2017::aid-cncr2820680929>3.0.co;2-v
Subject(s) - medicine , phyllodes tumor , oncology
The authors studied prognostic factors in 77 patients with primary cystosarcoma phyllodes (CSP) of the breast. Median patient age was 50 years of age, and the median follow‐up time was 8 years. Sixteen patients (21%) had distant metastases and subsequently died of CSP. Clinical variables such as age, symptom duration, clinical tumor size, and type of surgery were not of prognostic value. Local recurrence was more common among patients treated with breast‐conserving surgery than among those treated with mastectomy. However, there was no significant difference between these two subgroups in terms of distant metastasis‐free survival or overall survival. The prognostic significance of several histopathologic parameters was also assessed, e.g., stromal cellularity, stromal cellular atypism, mitotic activity, atypic mitoses, stromal overgrowth, tumor contour, tumor necrosis, and heterologous stromal elements. In a multivariate Cox analysis, the only features that were found to be independent prognostic factors were tumor necrosis ( P < 0.05) and presence of stromal elements other than fibromyxoid tissue ( P < 0.01). In summary, additional studies of prognostic factors in CSP are warranted because of the conflicting results in published reports.