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Endometrial carcinoma with trophoblastic differentiation. An aggressive form of uterine cancer
Author(s) -
Pesce Carlo,
Merino Maria J.,
Chambers Joe T.,
Nogales Francisco
Publication year - 1991
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19911015)68:8<1799::aid-cncr2820680825>3.0.co;2-3
Subject(s) - syncytiotrophoblast , medicine , human chorionic gonadotropin , carcinoma , multinucleate , adenocarcinoma , immunohistochemistry , choriocarcinoma , cancer , endometrial cancer , trophoblast , giant cell , uterine cancer , pathology , oncology , pregnancy , placenta , fetus , hormone , biology , genetics
Three cases of poorly differentiated endometrial adenocarcinoma showing trophoblast‐like differentiation are reported. The multinucleated, syncytiotrophoblast‐like cells were strongly positive for β‐human chorionic gonadotropin (β‐HCG) by immunohistochemical study. High levels of β‐HCG were also present in the patients' serum, but dropped significantly after treatment. The patients had an unusually rapid and progressive clinical course with widespread dissemination and death by tumor.