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Granular cell tumor of a digital nerve
Author(s) -
Enghardt Michael H.,
Jordan Steve E.
Publication year - 1991
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19911015)68:8<1764::aid-cncr2820680820>3.0.co;2-#
Subject(s) - granular cell tumor , digital nerve , pathology , medicine , granular cell , immunostaining , schwann cell , anatomy , immunohistochemistry , central nervous system , endocrinology
Granular cell tumor is an infrequently encountered albeit not rare neoplasm considered to be of neuroectodermal origin. An example of a benign granular cell tumor originating within a digital nerve is presented. The authors employed routine light microscopic techniques and immunostaining which demonstrate features of the granular cells reflecting structural and functional characteristics of Schwann's cells and support neuroectodermal derivation. Granular cell tumor is ubiquitous in location but occurs more frequently in tongue, skin, and subcutaneous tissue. Clinical features are not specific, and a histologic evaluation is required for diagnosis. Circumscription and lack of cellular pleomorphism define a benign process. However, irrespective of its histologic appearance, the biologic potential is uncertain. Complete excision suffices as treatment for benign tumors.