Premium
Successful use of cisplatin to treat metastatic seminoma during cisplatin‐induced acute renal failure
Author(s) -
Fox Jonathan G.,
Kerr David J.,
Soukop Michael,
Farmer John G.,
Allison Marjorie E. M.
Publication year - 1991
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19911015)68:8<1720::aid-cncr2820680812>3.0.co;2-a
Subject(s) - cisplatin , medicine , carboplatin , seminoma , regimen , urology , hemodialysis , nephrotoxicity , renal function , radiation therapy , acute kidney injury , chemotherapy , oncology , kidney
Abstract A chemotherapeutic regimen including cisplatin was administered to a man with extragonadal seminoma and cisplatin‐induced acute renal failure. Three doses of cisplatin (30, 50, and 100 mg/m 2 ) were given in conjunction with hemodialysis. Pharmacokinetic data for free and total plasma platinum were obtained. The patient also received one dose of carboplatin and a course of radiation therapy. Complete remission was achieved, and useful renal function returned. Cisplatin can be used successfully during acute renal failure.