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Later recurrence and longer survival among obese patients with renal cell carcinoma
Author(s) -
Yu MeiLin,
Asal Nabih R.,
Geyer James R.
Publication year - 1991
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19911001)68:7<1648::aid-cncr2820680731>3.0.co;2-5
Subject(s) - medicine , hazard ratio , renal cell carcinoma , confidence interval , body mass index , proportional hazards model , obesity , carcinoma , disease , obesity paradox , kidney disease , gastroenterology , surgery , oncology , overweight
To investigate the effect of obesity at diagnosis on prognosis of renal cell carcinoma, 360 renal cell carcinoma patients newly diagnosed at 29 hospitals in Oklahoma between January 1, 1981 and December 31, 1984 were followed through December 31, 1987. The Cox proportional‐hazard model was used to estimate the hazard ratio, adjusting for other potentially prognostic factors. Both the disease‐free interval and the overall survival were longer in patients who were obese (≧ 120% standard body mass index) at diagnosis. The adjusted‐hazard ratio for disease recurrence between obese and nonobese patients was 0.43 (95% confidence interval [CI], 0.19 to 0.98). The obese patients had an adjusted death hazard rate 0.68 times that of the nonobese patients (95% CI, 0.38 to 1.22). Although obesity was reported to increase the risk for renal cell carcinoma, prognosis was no worse and may be better among obese patients with the disease.