Premium
Prolactin‐producing pituitary carcinoma with pulmonary metastases
Author(s) -
Atienza Daniel M.,
Vigersky Robert J.,
Lack Ernest E.,
Carriaga Marisa,
Rusnock Eileen J.,
Tsou Edward,
Cerrone Federico,
Kattah Jorge G.,
Sausville Edward A.
Publication year - 1991
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19911001)68:7<1605::aid-cncr2820680723>3.0.co;2-d
Subject(s) - medicine , prolactin , pathology , lung , pituitary gland , carcinoma , disease , immunohistochemistry , pituitary neoplasm , hormone
Pituitary adenomas rarely are metastatic. Extracranial visceral metastases of prolactinomas were not previously reported. The authors report a case of a 34‐year‐old man with a prolactin‐producing pituitary carcinoma and histologically proven lung metastases. Pathologic examination of the pulmonary spread included electron microscopy and immunohistochemistry; these confirmed prolactin production by the tumor. The patient's presentation at initial diagnosis, disease recurrence, clinical course, management and response to therapy (with its theoretic basis) are detailed. Despite the use of dopamine analogues (to tolerance and in combination), there was documented intracranial and extracranial disease progression. Possible future therapeutic maneuvers are discussed.