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Isolated incisional metastases after intraperitoneal radioactive chromic phosphate therapy for ovarian carcinoma
Author(s) -
Kohler Matthew F.,
Soper John T.,
Allan Jr J. Tucker,
ClarkePearson Daniel L.
Publication year - 1991
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19910915)68:6<1380::aid-cncr2820680633>3.0.co;2-u
Subject(s) - medicine , laparotomy , ovarian carcinoma , occult , adjuvant therapy , cisplatin , surgery , carcinoma , chemotherapy , ovarian cancer , oncology , pathology , cancer , alternative medicine
Two women developed apparently isolated recurrences of ovarian carcinoma involving prior incisions after receiving intraperitoneal radioactive chromic phosphate (P‐32) adjuvant therapy for early epithelial ovarian carcinoma. Both are alive without evidence of disease at second‐look laparotomy after surgical resection of the abdominal wall metastases and cisplatin‐based combination chemotherapy. Mechanisms of cutaneous and incisional implantation metastases are discussed. Adjuvant therapy with intraperitoneal P‐32 is unable to provide systemic therapy for occult metastatic disease. The favorable outcome in these cases probably reflects limited tumor burden at the time of recurrence and stands in stark contrast to other cases of soft tissue recurrences of ovarian carcinoma reported previously.