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A case of adenocarcinoma of the lung associated with a neck mass and hypercalcemia
Author(s) -
Benisovich Vladimir I.,
Rybak Benito J.,
Ross Frank A.
Publication year - 1991
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19910901)68:5<1106::aid-cncr2820680534>3.0.co;2-3
Subject(s) - medicine , malignancy , adenocarcinoma , parathyroid adenoma , metastasis , hypophosphatemia , autopsy , adenoma , pathology , neck mass , lung , cancer , incidence (geometry) , physics , optics
The case of hypercalcemia secondary to metastasis to a benign parathyroid adenoma is reported. The patient had documented lung adenocarcinoma with multiple bone metastases and a mass in the lower anterior neck for at least 5 months before hypercalcemia and hypophosphatemia resistant to treatment developed. Autopsy revealed widespread metastatic disease including metastatic tumor invading a benign parathyroid adenoma. The analysis of four cases of metastatic cancer spread to a benign parathyroid adenoma reported previously revealed that two of them also had hypercalcemia during a late stage of the disease. There are data that the incidence of metastases to parathyroid gland might be as high as 11.9%, and the incidence of parathyroid adenomas in patients with cancer is significantly higher than in controls. The metastases to benign parathyroid adenomas might be another mechanism of hypercalcemia of malignancy.