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An unusual family cancer syndrome manifested in young siblings
Author(s) -
Weinblatt Mark,
Kochen Joseph
Publication year - 1991
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19910901)68:5<1068::aid-cncr2820680526>3.0.co;2-q
Subject(s) - medicine , cancer , sarcoma , ovary , ovarian cancer , chemotherapy , disease , germ cell tumors , childhood cancer , germ cell , pathology , oncology , genetics , biology , gene
Three siblings whose mother had an ovarian mass excised as a teenager all developed malignancies in late childhood. Two were diagnosed as having malignant germ cell tumors of the ovary, whereas the third was found to have a soft tissue sarcoma. No underlying familial disease or constitutional chromosomal aberration has been detected and no known carcinogenic chemical exposure has been identified. All three children have been successfully treated with chemotherapy and are doing well off treatment. This is the first family cancer syndrome reported to have an association of ovarian germ cell tumors with embryonal sarcoma.