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Immunologic observations in close relatives of two sisters with mammary Burkitt's lymphoma. Mammary Burkitt's lymphoma in sisters
Author(s) -
Poulsen Lene O.,
Christensen Jeppe Hagstrup,
Sørensen Bente,
Ebbesen Peter,
Pallesen Gorm,
Grunnet Niels
Publication year - 1991
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19910901)68:5<1031::aid-cncr2820680521>3.0.co;2-s
Subject(s) - serology , lymphoma , medicine , titer , antibody , antigen , virus , immunology , virology , antibody titer , burkitt's lymphoma , epstein–barr virus
In a sibship of four sisters, two had Burkitt's lymphoma localized to the breast. Their pretreatment Epstein‐Barr virus (EBV) serology were not examined. No EBV genome was demonstrated in the tumors using an in situ hybridizatinon technique. The mother showed an abnormal antibody response to EBV infection consisting of elevated IgA and IgG antibody titers to viral capsid antigen (VCA) and high IgG antibody titer to early antigen. Furthermore, one of the two healthy sisters showed elevated IgG antibody titer to VCA. The EBV serology is mimicking the findings in female carriers of the X‐linked lymphoproliferative syndrome.