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Diffuse large cell lymphoma occurring in a patient with waldenström's macroglobulinemia. Evidence for the two different clones in richter's syndrome
Author(s) -
Chubachi Akihiko,
Ohtani Hiroshi,
Sakuyama Masafumi,
Nimura Takashi,
Mamiya Shigeo,
Saitoh Masahiro,
Watanuki Tsutomu,
Miura Akira B.
Publication year - 1991
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19910815)68:4<781::aid-cncr2820680420>3.0.co;2-6
Subject(s) - macroglobulinemia , medicine , waldenstrom macroglobulinemia , chronic lymphocytic leukemia , lymphoma , lymphoplasmacytic lymphoma , pathology , immunoglobulin light chain , immunoglobulin m , antibody , leukemia , immunology , immunoglobulin g , multiple myeloma
The authors report a 60‐year‐old man with Richter's syndrome, or diffuse large cell lymphoma (DLCL) occurring in a patient with either chronic lymphocytic leukemia (CLL) or Waldenström's macroglobulinemia (WM). Surface marker analysis revealed that the WM showed μK surface immunoglobulin (Ig) chains, and that the DLCL showed μλ Ig chains. Flow cytometric DNA analysis demonstrated DNA content differences between WM and DLCL, the former diploid and the latter aneuploid. The current study suggests that Richter's syndrome derives from two independent B‐cell malignancies.