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Extramedullary blast crisis in chronic myelogenous leukemia. Demonstration of t‐cell lineage and philadelphia chromosome in a paraspinal tumor
Author(s) -
Sun Tsieh,
Susin Myron,
Koduru Prasad,
Coffey Edward L.,
Goh Jane,
Brody Judith,
Dittmar Klaus,
Weiss Rita
Publication year - 1991
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19910801)68:3<605::aid-cncr2820680327>3.0.co;2-y
Subject(s) - chronic myelogenous leukemia , medicine , lineage (genetic) , philadelphia chromosome , genotyping , penetrance , pathology , population , blast crisis , cancer research , leukemia , immunology , genetics , biology , genotype , chromosomal translocation , environmental health , gene , phenotype
A case of chronic myelogenous leukemia (CML) with penetrance of the Ph 1 molecular alteration into the T‐cell lineage of a paraspinal tumor is reported. The T‐cell nature of the paraspinal tumor was documented by immunochemical study and genotyping. The Philadelphia chromosome was also detected by genotyping in the same tumor cell population. To the authors' knowledge, this is the first case of extramedullary T‐cell blast crisis in CML demonstrated in an extranodal tumor. The clinical significance of detecting extramedullary blast crisis, and the theories for the scarcity of T‐cell transformation in CML are discussed.