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Natural history of vaginal intraepithelial neoplasia
Author(s) -
Aho Markku,
Vesterinen Ervo,
Meyer Bengt,
Purola Esko,
Paavonen Jorma
Publication year - 1991
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19910701)68:1<195::aid-cncr2820680135>3.0.co;2-l
Subject(s) - medicine , natural history , vagina , concomitant , vulvar intraepithelial neoplasia , cervical intraepithelial neoplasia , biopsy , intraepithelial neoplasia , carcinoma , vaginal cancer , gynecology , cancer , cervical cancer , dermatology , vulva , pathology , surgery , prostate
The natural history of vaginal intraepithelial neoplasia (VAIN) was studied in 23 patients followed for at least 3 years with no treatment. The mean age of the patients was 41 years of age. A large proportion of the VAIN lesions (50%) were multifocal, and approximately one half of the lesions were associated with concomitant cervical or vulvar intraepithelial neoplasia. Progression to invasive vaginal carcinoma occurred in two (9%) cases, persistence of VAIN occurred in three (13%) cases, and regression of VAIN occurred in 18 (78%) cases. The risk for progression to invasive carcinoma emphasizes the significance of colposcopic examination of the vagina with directed biopsy specimens obtained from all lesions.