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Immunohistochemical studies of blood group‐related antigens in human superficial esophageal carcinomas
Author(s) -
Tauchi Katsunori,
Kakudo Kennichi,
Machimura Takao,
Makuuchi Hiroyasu,
Mitomi Toshio
Publication year - 1991
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19910615)67:12<3042::aid-cncr2820671219>3.0.co;2-l
Subject(s) - immunohistochemistry , pathology , carcinoma , antigen , medicine , lymph node , epithelium , immunology
A total of 63 surgically resected esophageal carcinomas (including 49 superficial esophageal carcinomas) and histologically normal tissue adjacent to the superficial carcinoma (nontumorous epithelium) were examined immunohistochemically for the blood group antigens (BGA) A, B, H, Lewis a , Lewis b , Lewis x , and Lewis y . Deletion of an expected A, B or H antigen occurred in 12 (24.5%) of the 49 superficial carcinomas and three (21.4%) of the 14 advanced carcinomas. Incompatible expression of an unexpected A or B antigens occurred in only one case (1.6%) in the carcinoma. In the clinicopathologic study, there was a significant correlation between immunoreactivity of Lewis a and depth of cancer invasion (chi‐square test, P < 0.05). In the superficial carcinoma, there were significant correlations between immunoreactivity of Lewis x and lymph node status (chi‐square test, P < 0.05), immunoreactivity of Lewis y and prognosis (Z test, P < 0.05), and incompatible expression of Lewis b for tumor against nontumorous epithelium and histologic variation (chi‐square test, P < 0.01). The functional significance of alternations in BGA expression that may be associated with oncogenesis is not clear. However, immunohistochemical determination of BGA may be a more advantageous marker to predict the patient's clinical course in superficial esophageal carcinoma.