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Cytofluorometric analysis of metastases from lung adenocarcinoma with special reference to the difference between hematogenous and lymphatic metastases
Author(s) -
Nomori Hiroaki,
Nakajima Takashi,
Noguchi Masayuki,
Iga Rokuichi,
Shimosato Yukio
Publication year - 1991
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19910601)67:11<2941::aid-cncr2820671139>3.0.co;2-7
Subject(s) - lymph , medicine , adenocarcinoma , pathology , primary tumor , lung , lymphatic system , metastasis , adenocarcinoma of the lung , nuclear dna , cancer , biology , biochemistry , mitochondrial dna , gene
Metastatic tumors in the brain, liver, and regional lymph nodes (20 cases each) from patients with adenocarcinoma of the lung were examined by cytofluorometric analysis, and compared with the respective primary lung tumors. The nuclear DNA content of tumor cells was significantly increased in metastatic tumors in the brain and liver compared with the primary ( P < 0.01). However, the DNA content of metastatic tumors in regional lymph nodes was almost identical to that of the primary tumor in many instances. From the viewpoint of the nuclear DNA content of lung adenocarcinoma, blood‐borne tumor cells in the brain and liver were considered likely to constitute a discrete tumor cell subpopulation, i.e. , probably a more malignant one, different from the major subpopulation in the primary tumor, whereas lymphatic metastases in regional lymph nodes were similar to the primary. The subpopulation with an increased DNA content in hematogenous metastases were thought to have originated from a minor subpopulation in the primary tumor or to have developed at the metastatic site.