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Retinoblastoma. The long‐term appearance of radiated intraocular tumors
Author(s) -
Abramson David H.,
Ellsworth Robert M.,
Gerardi Cynthia,
Servodidio Camille A.,
Romanella Agnese,
McCormick Beryl,
Fass Daniel
Publication year - 1991
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19910601)67:11<2753::aid-cncr2820671107>3.0.co;2-f
Subject(s) - retinoblastoma , medicine , retrospective cohort study , ophthalmology , regression , pathology , biology , psychology , biochemistry , gene , psychoanalysis
A retrospective analysis of 50 patients with retinoblastoma was undertaken to determine the appearance of intraocular retinoblastoma that had received external beam radiation a minimum of 10 years previously. Of the 91 tumors found in 59 eyes, 76 (84%) continued to be ophthalmoscopically visible after 10 years. The most common ophthalmoscopic appearance was a Type III regression pattern. The type of radiation regression pattern correlated with the pretreatment volume of the tumor. The largest tumors (mean, 10.0 disc diameter [dd]) became Type I regression patterns, whereas the smallest tumors (mean, 1.0 dd) completely disappeared. This represents the first long‐term follow‐up of the intraocular status of radiated retinoblastoma.