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Congenital angiotropic lymphoma (intravascular lymphomatosis) of the T‐cell type
Author(s) -
Tateyama Hisashi,
Eimotoy Tadaaki,
Tada Toyohiro,
Kamiya Masuzou,
Fujiyoshi Yukio,
Kajiura Syouji
Publication year - 1991
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19910415)67:8<2131::aid-cncr2820670821>3.0.co;2-i
Subject(s) - medicine , pathology , lymphoma , bone marrow , immunohistochemistry , antibody , lymph , leukemia , immunology
The autopsy of a stillborn infant showed an extensive intravascular proliferation of atypical cells throughout the body. There was no infiltration by these cells of the parenchyma of the bone marrow, lymph nodes, or thymus. By histochemistry, these cells were negative for naphthol‐ASD‐chloroacetate esterase, a marker of granulocytes. By immunohistochemistry, they were reactive with MT‐1 and anti‐Leu‐22, but unreactive with MB‐1, L26, anti‐Leu‐M1, Tü‐9, and antihemoglobin antibodies. A few cells reacted with antileukocyte common antigen and UCHL‐1. Based on these findings, the lesion was diagnosed as angiotropic lymphoma (intravascular lymphomatosis) of the T‐cell type, which occurred congenitally. Most angiotropic lymphomas in the literature are of the B‐cell type, and no congenital case has been reported to the authors' knowledge. The anti‐human T‐cell leukemia virus type I antibody was negative in the mother.