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Meningeal involvement in bence jones multiple myeloma
Author(s) -
Oda Kenji,
Egawa Hiromi,
Okuhara Taneomi,
Sakai Akira,
Hyohdou Hideo,
Tanaka Hideo,
Kuramoto Atsushi
Publication year - 1991
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19910401)67:7<1900::aid-cncr2820670714>3.0.co;2-a
Subject(s) - medicine , multiple myeloma , cerebrospinal fluid , cytarabine , plasma cell leukemia , pathology , autopsy , bence jones protein , prednisolone , plasma cell , leptomeninges , leukemia , antibody , immunoglobulin light chain , gastroenterology , immunology , central nervous system
A case of Bence Jones kappa multiple myeloma with meningeal involvement in a 64‐year‐old woman is presented. Three years after the diagnosis of multiple myeloma, gait disturbances developed followed by visual disorders and impaired consciousness. A lumbar puncture revealed numerous atypical plasma cells in the cerebrospinal fluid. Craniospinal irradiation and intrathecal injections of methotrexate, cytarabine, and prednisolone were effective for a short period. At autopsy, the leptomeninges were infiltrated diffusely with atypical plasma cells. A review of the literature showed that multiple myeloma with meningeal involvement is accompanied frequently by circulating atypical plasma cells or plasma cell leukemia. Meningeal involvement is a rare complication and shows poor prognosis in cases of multiple myeloma.