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Solid and cystic pancreatic tumors. Clinical, histochemical, and electron microscopic features in ten cases
Author(s) -
Stömmer Peter,
Kraus Joachim,
Stolte Manfred,
Giedl Josef
Publication year - 1991
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19910315)67:6<1635::aid-cncr2820670627>3.0.co;2-m
Subject(s) - synaptophysin , enolase , pathology , medicine , chromogranin a , pancreas , immunohistochemistry , metastasis , electron microscope , endocrine system , cancer , physics , hormone , optics
Ten cases of the rare solid and cystic pancreatic tumors are presented. All except one occurred in young women (mean age, 25 ± 9.2 years). The large neoplasms were evenly distributed across the pancreas; in one case, metastasis occurred; all other cases were free from disease after complete resection. Histologic hallmarks of solid and cystic neoplasms were papillary growth, large intracytoplasmic granules, and immunoreactivity with α1‐antitrypsin, α1‐antichymotrypsin, phospholipase A2, and neuroendocrine markers (neuron‐specific enolase [NSE], synaptophysin). This suggests both endocrine as well as exocrine differentiation.