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Idiopathic hypereosinophilic syndrome terminating as disseminated T‐cell lymphoma
Author(s) -
Kim Chong Jai,
Park Seong Hoe,
Chi Je Geun
Publication year - 1991
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19910215)67:4<1064::aid-cncr2820670433>3.0.co;2-p
Subject(s) - medicine , organomegaly , lymphoma , eosinophilia , pathology , t cell lymphoma , malignancy , idiopathic pulmonary fibrosis , hypereosinophilic syndrome , lung , polyneuropathy
The Authors describe a case of idiopathic hypereosinophilic syndrome (HES) terminated as a T‐cell lymphoma in a 3‐year‐old girl. The clinical course was chronic and characterized by chronic eczema, persistent peripheral blood eosinophilia, organomegaly, interstitial lung change, and pericarditis. Postmortem examination demonstrated a disseminated T‐cell lymphoma involving the inguinal lymph node, liver, lung, and kidney. The findings of the current case suggest a possibility that certain abnormalities in this case of idiopathic HES per se may have triggered the development of malignant lymphoma, and it may represent a transition of idiopathic HES into a T‐cell lymphoma. Other possible sequences are discussed. The development of T‐cell malignancy in idiopathic HES in a girl is quite an unusual presentation.