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Immunosuppressive acidic protein in malignant diseases. Clinical relevance?
Author(s) -
Glück Stefan,
Köster Wolf
Publication year - 1991
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19910201)67:3<610::aid-cncr2820670315>3.0.co;2-u
Subject(s) - medicine , relevance (law) , dermatology , law , political science
The immunosuppressive acidic protein (IAP) has been described as a tumor associated marker in some solid tumors and hematologic diseases. To define the clinical relevance the authors determined the serum IAP levels in 194 patients with malignancies before initiation of therapy, 14 patients with idiopathic thrombocytopenic purpura (ITP), 28 patients with bacterial pneumonia, and 23 healthy volunteers. Immunosuppressive acidic protein was measured by radial immunodiffusion. The mean value of our controls was 405 ± 48 μg/ml. This is consistent with published data. The mean values for patients with malignancies varied from 554 μg/ml to 698 μg/ml. These are only marginally higher than those observed for the controls. In contrast patients with bacterial pneumonia demonstrated significantly elevated values (1038 ± 261 μg/ml). The authors conclude that IAP cannot be used as a diagnostic marker for the malignant diseases examined in this study.