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Nucleolar organizer regions in precancerous and cancerous lesions of the bronchus
Author(s) -
Abe Shosaku,
Ogura Shigeaki,
Kunikane Hiroshi,
Suko Noriaki,
Watanabe Naomi,
Nakajima Isao,
Kawakami Yoshikazu,
Inoue Kazuaki
Publication year - 1991
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19910115)67:2<472::aid-cncr2820670225>3.0.co;2-n
Subject(s) - pathology , squamous metaplasia , medicine , epithelium , carcinoma in situ , metaplasia , staining , nucleolus organizer region , carcinoma , lesion , bronchus , adenocarcinoma , squamous carcinoma , basal cell , silver stain , respiratory disease , cancer , lung , nucleus , nucleolus , psychiatry
Using a silver staining technique, nucleolar organizer region‐associated proteins (Ag‐NOR) were studied in paraffin sections of five specimens of normal bronchial epithelium, eight of atypical squamous metaplasia, five of carcinoma in situ , and seven of microinvasive squamous cell carcinoma. The mean number of Ag‐NOR in the nucleus were normal epithelium 1.2 ± 0.1 (mean ± SD), atypical squamous metaplasia (borderline lesion) 2.2 ± 0.5, carcinoma in situ 3.8 ± 0.6, and microinvasive squamous cell carcinoma 4.8 ± 1.1. There was a highly significant difference between the Ag‐NOR numbers in the atypical squamous metaplasia and those in the carcinoma in situ (P < 0.01). The Ag‐NOR staining is a useful technique for the differential diagnosis of difficult borderline lesions in the bronchial epithelium.