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The interferon system in carcinoma of the cervix. Effect of radiation and chemotherapy
Author(s) -
Chadha K. C.,
Ambrus J. L.,
Halpern J.,
Khalil M.,
Sayyid S.,
Piver M. S.,
Hreshchyshyn M. M.
Publication year - 1991
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19910101)67:1<87::aid-cncr2820670117>3.0.co;2-x
Subject(s) - medicine , chemotherapy , interferon , cervix , radiation therapy , carcinoma , oncology , interferon alfa , alpha interferon , gastroenterology , cancer , immunology
Thirteen patients with advanced carcinoma of the cervix were studied for parameters of the interferon system compared with 40 age‐matched and sexmatched controls. All patients had measurable serum interferon levels; controls did not. All patients had non‐antibody‐type interferon‐inhibitory activity, and controls had none. Interferon‐synthesizing potential was higher in controls than in patients. After successful radiation and chemotherapy, these parameters normalized in the patients. No change was seen in one patient who did not respond to therapy.