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Distribution of immunoglobulins and secretory component in gastric cancer of the aged
Author(s) -
Takemura Kazuo,
Hirokawa Katsuiku,
Esaki Yukiyoshi,
Mishima Yoshio
Publication year - 1990
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19901115)66:10<2168::aid-cncr2820661021>3.0.co;2-2
Subject(s) - medicine , cancer , secretory component , antibody , distribution (mathematics) , component (thermodynamics) , immunology , mathematical analysis , physics , mathematics , thermodynamics
The secretory immune system plays an important role in the local humoral immunity of the gastrointestinal tract. in order to evaluate humoral immunity in gastric cancer, distribution of immunoglobulins (Ig) and secretory component was immunohistochemically studied in 74 early and 15 advanced primary gastric cancers. in non‐cancerous gastric mucosa, IgA and IgM, and secretory component were mainly identified in the cytoplasm of the intestinal metaplasia. in early gastric cancer of well‐differentiated type, the localization of IgA and IgM, and secretory component was similar to that of intestinal metaplasia. in advanced gastric cancer, they were faintly observed and showed low positivity. the number of Ig‐containing cells infiltrating cancerous stroma was enumerated. Immunoglobulin A‐containing cells were dominant in the stroma of early gastric cancer. On the other hand, there were few Ig‐containing cells in the stroma of advanced gastric cancer, and the number of IgA‐containing and IgM‐containing cells was also decreased. These results suggest that local humoral immunity is suppressed in gastric cancer, especially in advanced gastric cancer.