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Occurrence of beta‐hexachlorocyclohexane in breast cancer patients
Author(s) -
MussaloRauhamaa H.,
Häsänen E.,
Pyysalo H.,
Antervo K.,
Kauppila R.,
Pantzar P.
Publication year - 1990
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19901115)66:10<2124::aid-cncr2820661014>3.0.co;2-a
Subject(s) - hexachlorocyclohexane , breast cancer , medicine , odds ratio , beta (programming language) , oncology , logistic regression , physiology , cancer , biology , pesticide , computer science , agronomy , programming language
The residues of polycyclic aromatic hydrocarbon (PAH) and neutral organochlorine compounds in breast fat of 44 breast cancer patients and 33 women free of cancer were determined. No statistically significant differences appeared between the two comparison groups with regard to occurrence of PAH compounds. of the neutral organochlorine compounds, residues of beta‐hexachlorocyclohexane (HCH) were found more frequently in breast cancer patients. After adjusting for age and parity by stepwise logistic regression, beta‐HCH remained a significant risk factor of breast cancer. Using a cutoff point for the residue level of beta‐HCH in breast adipose tissue of more than 0.1 mg/kg fat, the odds ratio was 10.51 (95% CI, 2.00–55.26).