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Toxic dermatitis induced by 10‐ethyl‐10‐deazaaminopterin (10‐EdAM), a novel antifolate
Author(s) -
Verweij Jaap,
Schornagel Jan,
De Mulder Pieter,
HenzenLogmans Sonja,
Cognetti Francesco,
Clavel Michel,
Vermorken Jan
Publication year - 1990
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19901101)66:9<1910::aid-cncr2820660909>3.0.co;2-2
Subject(s) - medicine , methotrexate , antifolate , discontinuation , rash , concomitant , aminopterin , antimetabolite , toxicity , dermatology , pharmacology , surgery
A new methotrexate analog, 10‐ethyl‐10‐deaza‐aminopterin (10‐EdAM), was found to induce a particular form of skin toxicity different than the skin rash reported to result from methotrexate. At histologic examination, it was found to be a toxic dermatitis that clinically most often first appears on the lower legs but can occur anywhere in the body, especially if treatment is continued. Nine cases are reported. A specific risk factor could not yet be identified. Discontinuation of 10‐EdAM administration leads to complete healing; concomitant corticosteroid treatment also induces healing.