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Targeting cancer chemotherapeutic agents by use of lipiodol contrast medium
Author(s) -
Konno Toshimitsu
Publication year - 1990
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19901101)66:9<1897::aid-cncr2820660907>3.0.co;2-j
Subject(s) - lipiodol , medicine , cancer , contrast medium , doxorubicin , liver cancer , nuclear medicine , chemotherapy , pathology , surgery , radiology , embolization
Arterially administered Lipiodol Ultrafluid contrast medium selectively remained in various malignant solid tumors because of the difference in time required for the removal of Lipiodol contrast medium from normal capillaries and tumor neovasculature. Although blood flow was maintained in the tumor, even immediately after injection Lipiodol contrast medium remained in the neovasculature of the tumor. To target anti‐cancer agents to tumors by using Lipiodol contrast medium as a carrier, the characteristics of the agents were examined. Anti‐cancer agents had to be soluble in Lipiodol, be stable in it, and separate gradually from it so that the anti‐cancer agents would selectively remain in the tumor. These conditions were found to be necessary on the basis of the measurement of radioactivity in VX2 tumors implanted in the liver of 16 rabbits that received arterial injections of 14 C‐labeled doxorubicin. Antitumor activities and side effects of arterial injections of two types of anti‐cancer agents were compared in 76 rabbits with VX2 tumors. Oily anti‐cancer agents that had characteristics essential for targeting were compared with simple mixtures of anti‐cancer agents with Lipiodol contrast medium that did not have these essential characteristics. Groups of rabbits that received oily anti‐cancer agents responded significantly better than groups that received simple mixtures, and side effects were observed more frequently in the groups that received the simple mixtures. These results suggest that targeting of the anti‐cancer agent to the tumor is important for treatment of solid malignant tumors.