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Primary leptomeningeal B‐cell lymphoma in an 8‐year‐old child
Author(s) -
Hayani Ammar,
Venger Benjamin H.,
Rouah Emilie,
Laurent John P.,
Mahoney Donald H.,
McClain Kenneth L.
Publication year - 1990
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19901015)66:8<1856::aid-cncr2820660835>3.0.co;2-n
Subject(s) - medicine , vincristine , cyclophosphamide , methotrexate , hypogammaglobulinemia , lymphoma , dexamethasone , prednisone , serology , chemotherapy , pathology , antibody , immunology
A case of primary leptomeningeal B‐cell lymphoma in an 8‐year‐old, previously healthy child is described. The child was found to have hypogammaglobulinemia, and the Epstein‐Barr virus genome was identified in cultured tumor cells despite blood serology being negative for the virus. The patient was treated with cyclophosphamide, doxorubicin, vincristine, and dexamethasone, plus intrathecal methotrexate, and initially improved. Before the initiation of craniospinal radiation, the patient developed progressive disease, deteriorated, and died 9 months after the onset of symptoms.