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Squamous cell carcinoma in epidermolysis bullosa. Treatment with systemic chemotherapy
Author(s) -
Lentz Steven R.,
Raish Robert J.,
Orlowski Edward P.,
Marion Jay M.
Publication year - 1990
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19900915)66:6<1276::aid-cncr2820660629>3.0.co;2-a
Subject(s) - medicine , epidermolysis bullosa , chemotherapy , dermatology , basal cell , incidence (geometry) , toxicity , epidermolysis bullosa dystrophica , pathology , oncology , physics , optics
Dystrophic epidermolysis bullosa is associated with a high incidence of cutaneous squamous cell carcinoma. Despite aggressive surgical treatment, metastases occur frequently, and survival is generally poor. Chemotherapy for advanced disease has usually been avoided because of the potential for severe cutaneous toxicity. Two patients with autosomal recessive dystrophic epidermolysis bullosa and advanced squamous cell carcinoma are described. Both received cisplatin‐based systemic chemotherapy without significant toxicity.